The serum enzyme elevations were compatible with mild metronidazole hepatotoxicity, given the short latency period and rapid recovery after stopping. A legend at the bottom of the page lists all compatibility types, and hovering your mouse over the icon will open a popup with the full. Another online source supported by trissels states that our pharmacy subscribes to states the drug has not been tested with these or other standard iv solutions. Detailed metronidazole dosage information for adults and children. Metronidazole intravenous infusion 500 mg100ml medsafe. Metronidazole is a nitroimidazole antibiotic that is metabolised to an active metabolite. Metronidazoleclaris metronidazole intravenous infusion. Skinandskinstructureinfections,boneandjointinfections,complicated and uncomplicated urinary tract infections, uncomplicated gynecological in. Monographs for commonly administered intravenous medications in home and community care 3 p a g e metronidazole toxicity and kidney damage. Plasma concentrations of metronidazole are proportional to the administered dose. Prophylactic use of metronidazole injection, usp rtu should be limited to the day of surgery only, following the above guidelines. Yesterday a patient had fluids running and i had to start a flagyl piggyback. Metronidazole, injection, solution, 500 mg100ml, intravenous, general injectables and vaccines, inc.
Intravenous compatibility chartcisatracurium nimbex dexmedetomidine precedex dobutamineacyclovir acyclovir. Includes dosages for bacterial infection, skin or soft tissue infection, skin and structure infection and more. Calcium chloride ampicillin ampicillin yes calcium. Intravenous levofloxacin and metronidazole are currently not administered simultaneously, as studies regarding their compatibility are lacking. Intravenous compatibility chart free html5 flip book. Metronidazole injection is used to treat serious bacterial infections in different areas of the body. Additives should not be introduced into metronidazole injection, usp rtu.
Clinical pharmacology in patients treated with flagyl, using a dosage regimen of 15 mgkg loading dose. Trissel, fashp, 2010, american society of healthsystem pharmacists. Im a block 3 nursing student just starting to do iv fluids. I first looked in the iv drug book and there was no info on that fluids being okay. Flagyl metronidazole hydrochloride 500 mg for injection. Food and drug administration, silver spring, maryland. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. A hospitalwide solution for pharmacists, physicians and nurses, lexicomp provides clinicians access to two drug information resources within a single interface. An eighthour intravenous infusion of 100 mg to 4,000 mg of metronidazole in. Iv compatibility results are organized onto separate tabs, so that you can quickly access the route or method in which you are interested. Thames valley ysite intravenous drugs compatibility chart march 2011 prepared by the thames valley critical care network pharmacists group vecuronium 2011, thames valley critical care network pharmacists group version 2.
Flagyl and protonix drug interactions a study of fda data. Metronidazole, marketed under the brand name flagyl among others, is an antibiotic and antiprotozoal medication. I had to check compatability of that fluid, d5 12ns 20kcl, with the flagyl. This study is created by ehealthme based on reports of 1,080 people who take flagyl and protonix from food and drug administration fda, and is updated regularly.
The essential information you need to safely administer more than 400 intravenous drugs. Metronidazole c6h9n3o3 cid 4173 structure, chemical names, physical and. The admixture is stable for 24 hours at room temperature only in 0. Flagyl and magnesium sulfate drug interactions a study of. Commercially available metronidazole injection for iv infusion does not need to be diluted or neutralized prior to iv administration. Compatibility depends upon many factors including temperature, ph, iv fluid, concentration, order of mixing and brand of drug. Pn solutions are diverse in their composition and compatibilities with drugs can never be guaranteed.
Whats interesting is that trissels 2011 book states it has been tested with sodium chloride which ours is premixed in and dextrose 5%. Flagyl compatibility with d512ns patient medications. Metronidazole hydrochloride powder for injection must by reconstituted, diluted, and then neutralized prior to iv administration. Flagyl is a nitroimidazole antibiotic and zosyn is a combination of a penicillinclass antibacterial and a betalactamase inhibitor. Monitor lithium levels and serum creatinine every 3 days during treatment and after completing the metronidazole course until stable lithium levels are attained. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Vancomycin administered orally is the regimen of choice. National library of medicine national institutes of health. Route onset peak duration metronidazole metroenida. Incompatibilities are based on meeting any of the following criteria. For solution and drug compatibility information, see compatibility under stability. The national library of medicine nlm, on the nih campus in bethesda, maryland, is the worlds largest biomedical library and the developer of electronic information services that delivers data to millions of scientists, health professionals and members of the public around the globe, every day. Metronidazole for veterinary use wedgewood pharmacy. Monographs for commonly administered intravenous medications in home and community.
Intravenous compatibility chart acyclovir acyclovir. The antibiotics are listed on the yaxis and along the xaxis are the most commonly used iv solutions. Flagyl and zosyn are different types of antibiotics. Parenteral nutrition pn and drug compatibility the coinfusion of drugs and pn should be avoided. This study is created by ehealthme based on reports of 251 people who take flagyl and magnesium sulfate from food and drug administration fda, and is. Check tubing below ysite carefully for discoloration, cloudiness or precipitation. Ysite injection drug compatibility chart for general wards. This table was compiled for the convenience of the pharmacists tending to calls about iv compatibility. Metronidazole injection metronidazole dose, indications. You can publish your book online for free in a few minutes. Commercially available metronidazole injection for iv infusion does not. Drugs administered to patients receiving pn should be given through a separate iv site or catheter lumen. Compatibility with intravenous infusions and other drugs metronidazole solution for infusion may be diluted to 1 in 5 or greater with appropriate volumes of sodium chloride 0.
Recent publications include portions of the pill book guide to medication for your. While physically compatible with compound sodium lactate infusion. A handbook for nurses and health professionals has been a trusted resource for comprehensive drug coverage, unparalleled accuracy, and an intuitive quickaccess format. Metronidazole intravenous route description and brand. Flagyl, flagyl er metronidazole dosing, indications. I had a patient who had d5 12 ns running and an order of flagyl piggybacked.
Thames valley ysite intravenous drugs compatibility chart. Metronidazole injection, usp rtu is to be administered by slow intravenous drip infusion only, either as a continuous or intermittent infusion. The differences in uv spectra of metronidazole dis. See what the interactions are and for which people. I looked to see if the two were compatible in our drug reference page and i didnt see anything regarding the fluids so i called pharmacy. Physical and chemical compatibility of intravenous. It is compatible with many other antibiotics including penicillin antibiotics. Antibiotic compatibility chart wes cains health science. Claris, metronidazole intravenous infusion 500 mg100ml 2. How to use metronidazole solution, intravenous piggyback.
Flagyl yes metronidazole flagyl yesmidazolam versed yes midazolam versed. Physical and chemical compatibility of intravenous zanco j. Learn about drug interactions between acetaminophen iv and metronidazole iv and use the rxlist drug interaction checker to check drug combinations. Metronidazole 500mg100ml intravenous infusion is indicated in adults and children when oral medication is not possible for the following indications. Further dilute vials with compatible iv solution i. However, idiosyncratic cases are also marked by short latency period and rechallenge. Pharmacy said they werent aware of any compatibility so they told me to play it s. Metronidazole hydrochloride powder for injection should be protected from. Meanwhile, metronidazole and fluconazole were given through intermittent. Drugs az pill identifier supplements symptom checker diseases dictionary media. Drug interactions with acetaminophen iv and metronidazole iv.
For patients receiving metronidazole iv for the first time, the first dose should be given in the hospital or. Flagyl, flagyl er, and flagyl injection metronidazole and zosyn piperacillin and tazobactam for injection are antibiotics used to treat bacterial infections. While glucose 10% is compatible with metronidazole infusion, its use as a. Metronidazole belongs to the class of medicines known as antibiotics. Compatibility is denoted by an icon and simple description. Metronidazole injection, usp, in 100 ml viaflex plus single dose plastic container, is a sterile, nonpyrogenic, isoosmotic, buffered solution of 500 mg metronidazole, usp, 790 mg sodium chloride, usp, 47. Metronidazole solution, intravenous piggyback webmd. Drug interactions are reported among people who take flagyl and magnesium sulfate together. Lexicomp provides clear, concise, pointofcare drug information, including dosing, administration, warnings and precautions, as well as clinical content, such as clinical practice guidelines, iv compatibility from. Electronic orange bookapproved drug products with therapeutic equivalence evaluations. Do not give simultaneously with continuous calcium infusions.
Intravenous compatibility chart drug information for the. Flagyl 500mg100ml solution for infusion emc print friendly confidex is the worlds leading supplier of highperforming contactless ticketing and rfid tag solutions and services to make to make supply chains, transactions. Drug interactions are reported among people who take flagyl and protonix together. Critical care intravenous drug administration guide. Metronidazole iv does not require protection from light. This medication is given by injection into a vein as directed by your doctor, usually 3 or 4 times a day. The causes of metronidazole in compatibility are multifactorial. The rapid onset and rapid recovery after high doses of intravenous metronidazole suggest direct hepatic injury. Claris metronidazole intravenous infusion 500 mg100ml metronidazole.